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Paper Details

EFFECT OF GYMNEMA SYLVESTRE LEAVES EXTRACT ON GASTRIC ULCER

*Merai Ankit H and Anil G Jadhav

Journal Title:World Journal of Pharmaceutical Research
Abstract


Recently the world is turn to green/herbal pharmacy because the allopathic drug having major side effect. The main aim of present study was to evaluate the anti ulcer activity of Gymnema sylverstre. For the gastric ulcer there are varieties of drugs available but these drugs having major side effects. Bone structure alteration, iron deficiency anemia, risk of vitamin B 12 deficiency may cause by Cimetidine, Famotidine, Ranitidine, Sucralfate drugs use in gastric ulcer. Cardiac problems may also cause by proton pump inhibitors. Anti ulcer activity study was studied using different leaves extract like pet-ether, chloroform, alcohol, aqueous of Gymnema Sylverstre on different models of gastric ulcer, such as acetic acid induced chronic gastric ulcer, pylorus ligation and stress induced ulcer models. The extracts administered orally with the dose of 200mg/kg. All the extracts increase the healing process of ulcer (P< 0.05). But alcoholic extract was more significant when it compare with standard (P

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