• We are available for your help 24/7
  • Email: info@isindexing.com, submission@isindexing.com


Paper Details

SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL STUDIES OF BIOLOGICALLY ACTIVE BENZOTHIAZOLE DERIVATIVES

*D.Maruthamuthu, Dr. (Mrs.) P.Shameela Rajam, Dr. (Mrs.) P. Christina Ruby Stella, R.Ranjith

Journal Title:World Journal of Pharmaceutical Research
Abstract


A series of some benzothiazole was synthesized and evaluated for antimicrobial activity. The reaction of aniline compounds with ammonium thiocyante and HCl yielded 1 phenylthiourea. The title compounds were synthesized by treating 1-phenylthiourea with bromine in glacial acetic acid. Their structures were confirmed by IR, 1 H-NMR and 13 C-NMR spectral techniques. Docking study was done to find the binding capacity of the synthesized compounds with the protein molecule COX-2

Download