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Paper Details

HEPATOPROTECTIVE ACTIVITY OF AQUEOUS BARK EXTRACT OF ALSTONIA SCHOLARIS IN PARACETAMOL AND ETHANOL INDUCED LIVER DAMAGE IN ALBINO WISTAR RATS

G.V.Sampath Kumar*, Santosh Kumar Ranajit, Dr.K.Eswar Kumar

Journal Title:World Journal of Pharmaceutical Research
Abstract


The In vivo hepatoprotective effect of aqueous extract of Alstonia scholaris (AEAS) bark was evaluated in male rats against ethanol and paracetamol induced liver damage in preventive and curative models. Liver injury was induced by 40% ethanol administration (3.7 g/kg bw, orally) for 28 days and in the other case hepatic damage was induced by the administration of Paracetamol at a dose of 2g/kg bw for 11 days. In two different sets of experiments, the AEAS extracts (100, 200 and 400 mg/kg bw) and silymarin (100 mg/kg bw) were administered orally in preventive and curative models. Ethanol administration as well as Paracetamol administration caused severe hepatic damage in rats as evidenced by elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin levels. The AEAS and silymarin administration prevented the toxic effect of ethanol and Paracetamol on the above serum parameters in both preventive and curative models. The present study concludes that aqueous extract of Alstonia scholaris bark showed significant hepatoprotective activity against ethanol induced hepatotoxicity as well as Paracetamol induced hepatotoxicity.

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