SYNTHESIS OF PHARMACOLOGICAL ACTIVE 8-[2 / -(3 // , 5 // -DIMETHYL-4 // -ETHOXY CARBONYL PYRROLYL) HYDRAZINE] SUBSTITUTED PHENOTHIAZINES DERIVATIVES
Dr. Meghasham N. Narule*
Journal Title:World Journal of Pharmaceutical Research
Phenothiazine derivatives substituted in the 2, 3 and 4 positions belong
to a big group of tricyclic aromatic compounds. They are in extensive
use in psychiatry as tranquilizers and neuroleptics. Due to their
characteristic structure they exhibit many valuable analytical
properties. A short facile synthesis of 8-[2/-(3//, 5//-dimethyl-4//-ethoxy carbonyl pyrrolyl) hydrazine] substituted phenothiazines (5a-j)
from 2-arylamin benzal-2-(3?,5?-dimethyl-4?-ethoxy carbonyl
pyrrole)hydrazines (4) in presence of sulphur and iodine. These
compounds were screened for their antibacterial activity against S.
aureus and E. coli as well as for their antifungal activity against C.
albicans and A. niger. The synthesized compounds are characterized
H NMR, elemental and chemical properties.