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Paper Details

Quantitative evaluation of the mast cell population in border of ulcers in America Cutaneous LeishmaniasisACL

Cludio Gleidiston Lima da Silva

Journal Title:Basic Research Journal of Medicine and Clinical Science

American Cutaneous Leishmaniasis (ACL) is an infectious disease with a broad spectrum of presentation, has two clinical poles, one anergic and other hyperergic. The inflammatory response to the etiologic agent is complex and involves several cell lines, especially lymphocytes, plasma cells, histiocytes, and antigen-presenting cells. Other cells are observed in inflammatory exudate in a lesser degree, such as eosinophil and mast cells MC. Several studies have sought to investigate the role of mast cells in cutaneous Leishmaniasis. This study evaluated 64 skin biopsies of leishmanial ulcer edge. The number of mast cells and leishmania were observed in the timeline. It was found that the number of mast cells and leishmania decline with age of the lesion, there is a negative correlation p