Hypolipidemic and Anti-Ulcerative Effects of Cinnamomum Tamala (Nees.) (Bay Leaf) Extract on Hyperlipidemic and Indomethacin-Induced Gastric Ulcer in Male Wister Albino Rats.
Rita Oze,Gabriel Oze, Obijuru Tobias, Agomuo E. Emmanuel
Journal Title:Science View Journal
Cinnamomumtamalaleaf (Bayleaf) is a naturalspice usually preferred because of its food flavor and perceived medicinal values. This study investigated the effectof aqueousbay leaf extract (BLE) on hyperlipidermiaand gastric ulceration using male Wister strain albino rats. Forty two male rats weighing 150-200g,were fed with high fat diet (HFD) for 10 days. Hyperlipidemia was established. The rats were divided into 7 groups of 6 rats each. Group 1 received normal saline (5ml/kg) to serve as negative control. Group 2 was fed with HFD for 10 days. Group 3 was treated with 10mg/kg indomethacin (Indo) to induce gastric ulcer. Group 4 was challenged with 10mg/kg simvastatinstandard. Group 5 received 30mg/kg indo with 100 mg/kg cimetidine standard. The hyperlipidemic and ulcerogenic groups 6 and 7 were treated with 200 ad 400 mg/kg BLE respectively. In a dose dependent manner, the BLE significantly attenuated (p<0.05) the serumconcentrations of TC, Tg, LDL-C, and VLDL-C; and significantly elevated (p<0.05) the serum level of HDL-C. Similarly, the BLE significantly inhibited the ulcer score by 66.85 and 81.14% respectively, compared with the standard cimethidine, (76.28%). It is concluded that BLE exhibited considerable hypolipidemic and anti-ulcerative potentials. These may justify its use in folkmedicine practice to manage hypertension and to treat gastric ulcer related cases. Thisinvestigation needs to be sustained to elucidate the scientific mechanism for the observed effects.