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Paper Details

The Sea Star Igkappa Gene and The Ophuirid Igkappa Gene Vaccinations to HRP (Horse-radish Peroxydase)

The Sea Star Igkappa Gene and The Ophuirid Igkappa Gene Vaccinations to HRP (Horse-radish Peroxydase)

Michel Leclerc

Journal Title:Journal of Clinical And Experimental Immunology
Abstract


The main point of the sea star immunology, of the ophuirid immunology remain the discovery of the INVERTEBRATE PRIMITIVE ANTIBODY (IPA), the IGKAPPA GENES, with Ig sites which imply the COMPLEMENT SYSTEM, to be initiated: 9 component genes from C1 to C9 have been updated these last years, in sea star genome, in ophuirid one. These primitive antibodies were obtained after immunizations to the enzyme HRP (Horse-radish peroxydase). It is the first time we observe vaccinations in invertebrates. We have discovered, for the first time also, in these same Invertebrate a FC receptor gene, a Fab gene which corroborate the presence of IPA. The transcriptomes are given. It is the first time, we can speak of Adaptative Immunity, in Echinoderms, in Invertebrates Since many years, even since a century long, the notion of Antibody was out of the speech of immunologists. To speak of that made you as an outlaw. It is time to look with genomic studies which confirm which assert now evidence that 3 classes of Echinoderms out of 5 possess an Igkappa gene, a FC receptor gene. I recall these classent: the Asterids with Asterias rubens, the Ophuirids with Ophiocomina nigra and the Crinoïds.